Mathematical models of haploinsufficiency

Mathematical Modeling of Fluorination Reaction of Uranium Dioxide and Evaluation of Existing Gas-Solid Reaction Models

Tumor suppressor genetics.

The observation that mutations in tumor suppressor genes can have haploinsufficient, as well as gain of function and dominant negative, phenotypes has caused a reevaluation of the 'two-hit' model of tumor suppressor inactivation. Here we examine the history of haploinsufficiency and tumor suppressors in order to understand the origin of the 'two-hit' dogma. The two-hit model of tumor suppressor...

Two Mathematical Models for Railway Crew Scheduling Problem

Railway crew scheduling problem is a substantial part of the railway transportation planning, which aims to find the optimal combination of the trip sequences (pairings), and assign them to the crew complements. In this problem, each trip must be covered by at least one pairing. The multiple-covered trips lead to impose useless transfers called “transitions”. In this study, a new ma...

Mathematical Models for Microbial Kinetics in Solid-State Fermentation: A Review

  Context:In this review, we discuss empirical and stoichiometric models, which have been developed recently in SSF processes and the influence of environmental conditions on the variables of these models. Additionally, new studies on modeling of product formation are also mentioned. <span style="color: windowtext...

A review on West African Ebola epidemic dynamics models

Background and aims: The world is threatened by disease outbreak that reaches a public health emergency of international concern, studies to inform public and agencies for effective containment strategy are necessary. Several studies provided vital information of the dynamics and control of Ebola epidemic outbreak in West Africa. Methodologies and techniques in those researches...